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Calcium supplements and calcium-, aluminum-, and magnesium-containing medications may interfere with the absorption of Actonel and should be taken at a different time of the day. In postmenopausal women with osteoporosis, Actonel reduces the incidence of vertebral fractures and a composite endpoint of nonvertebral osteoporosis-related fractures [see Clinical Studies (14. Duodenitis and glossitis have been reported uncommonly in the Actonel 5 mg daily group (0. The duration of the trial was two years; 613 patients were exposed to Actonel 5 mg daily and 616 were exposed to Actonel 75 mg two consecutive days per month. Actonel is not recommended for use in patients with severe renal impairment (creatinine clearance <30 mL/min). 9% in the Actonel 5 mg daily group and 11.

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